Colorectal carcinoma: immunohistochemical staining for mismatch repair protein (MSH6). Note nuclear staining in a high proportion of the malignant cells. Mismatch Repair Protein (MSH6): clone EP49.

错配修复蛋白(MSH6)

mismatch-repair-protein-msh6
MSH6是一种160kD大小的蛋白质,与MSH2异二聚时参与DNA错配修复(MMR)和重组途径。错配修复系统中的缺陷可导致突变,并可导致DNA微卫星序列变得不稳定。免疫组化研究表明,MSH6在正常结肠上皮细胞的细胞核中有较强的表达,尤其是在隐窝中。淋巴细胞也有表达。研究还表明,MSH6在胃癌和子宫内膜癌中均有表达。然而,在某些伴有微卫星不稳定的子宫内膜癌和结肠癌中,表达有时会丢失。

Products

Products

MSH6-L-CE
1ml NCL-L-MSH6
查看可用性

Contact Us for a quote.

This item replaces MSH6-L-SMSH6-L-CE-SMSH6-LPA0597
PU29
Gastrointestinal Pathology
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0990
7ml MSH6 (EP49) Bond RTU Primary
查看可用性

Contact Us for a quote.

EP49
Gastrointestinal Pathology
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

下载

下载

MSH6-L-CE

PA0990

Recently Viewed