Colorectal carcinoma: immunohistochemical staining for mismatch repair protein (MSH2). Note nuclear staining in a high proportion of the malignant cells. Mismatch Repair Protein (MSH2): clone 79H11.

错配修复蛋白(MSH2)

mismatch-repair-protein-msh2
人错配修复蛋白2 (MSH2)在复制后的错配修复过程中,参与核苷酸错配的初始识别。因此,MSH2功能的丧失导致复制错误的积累,而复制错误的积累又可能导致多阶段癌变所需要的多重突变。据报道,MSH2在甲状腺、心脏、平滑肌和淋巴滤泡生发中心等多种组织的细胞核中均有表达。在回肠和结肠中,MSH2在隐窝中表达,隐窝中的细胞正在快速更新。它们负责分化细胞的持续产生,这些细胞在被甩入腔内之前会迁移2到4天。

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MSH2-612-L-CE
1ml NCL-L-MSH2-612
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79H11
Gastrointestinal Pathology
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0048
7ml MSH2 Bond RTU Primary
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This item replaces MSH2-CEMSH2MSH2-CE-S
25D12
Gastrointestinal Pathology
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0989
7ml MSH2 (79H11) Bond RTU Primary
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79H11
Gastrointestinal Pathology
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

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MSH2-612-L-CE

PA0048

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