11q23 / DLEU1 13q14 probe hybridized to MM patient material showing a 13q14 deletion (1R2G). Image kindly provided by Prof. Jauch, Heidelberg.
Hybridization results delineated 11q23 and 11q25 as the most frequently gained regions in Multiple Myeloma (MM) which supports a relevant pathogenetic role of genes in this region. Deletions of 13q14 are frequently detected by interphase FISH in patients with newly diagnosed MM, correlate with increased proliferative activity, and represent an independent adverse prognostic feature in MM. The 11q23 specific FISH probe is optimized to detect copy numbers at 11q23. The DLEU1 (13q14) specific DNA region is optimized to detect copy numbers of the DLEU1 (previously known as DLEU) gene region at 13q14.
References: Gonzalez et al, 2004, Haematologica, 89; 1213-1218. Cremer et al, 2005, Genes Chrom Cancer, 44; 194-203.