The translocation t(8;14)(q24;q32) is the characteristic chromosomal aberration of Burkitt’s-type of Lymphomas. This translocation fuses the MYC gene at 8q24 next to the IGH locus at 14q32, resulting in overexpression of the transcription factor MYC. Detection of the t(8;14) is aimed to help in the diagnostic process of patients with high-grade B-cell lymphomas because treatment strategies differ between Burkitt and other high-grade lymphomas.
MYC (8q24) Break, TC and MYC (8q24) Break, TC (tissue)
Rearrangements of the proto oncogene MYC have been consistently found in tumor cells of patients suffering from Burkitt’s lymphoma. In cases with the common t(8;14) chromosomal translocation, the MYC gene is translocated to chromosome 14 and rearranged with the immunoglobulin heavy chain genes; the breakpoint occurs 5’ to the c-myc gene and may disrupt the gene itself separating part of the first untranslated exon from the remaining two coding exons. In Burkitt’s lymphoma showing the variant t(2;8) or t(8;22) translocations, the genes coding for the k and l immunoglobulin light chain are translocated to chromosome 8.
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