SRD (1p36) / SE 1 probe hybridized to a normal metaphase (2R2G).
IVD SRD/SE 1
Neuroblastomas frequently have deletions of chromosome 1p and amplification of the MYCN oncogene. These deletions tend to be large and extend to the telomere, but a common region within sub-band 1p36.3 is consistently lost in these deletions. Inactivation of a tumor suppressor gene within 1p36.3 is believed to be associated with an increased risk for disease relapse. The SRD (1p36) FISH probe is optimized to detect copy numbers of the 1p36 region on chromosome 1. The chromosome 1 satellite enumeration probe (SE 1) at 1qh is included to facilitate chromosome identification.
References: Caron et al, 1993, Nat Genet, 4: 187-190. Cheng et al, 1995, Oncogene, 10: 291-297. White et al, 2005, Oncogene, 24: 2684-2694.