Mm-BCR / ABL1 probe hybridized to patient material showing t(9;22) with M-BCR (1F1r1R1G).


Breakpoints in the BCR gene region can occur in different regions, predominantly in a major breakpoint cluster region (M-BCR) but can also occur in a minor breakpoint cluster region (m-BCR) or micro breakpoint cluster region (µ-BCR). Further research has indicated that CML patients with different BCR-ABL1 transcripts respond differently to treatment with Gleevec. The Mm-BCR/ABL1 t(9;22), Dual-Color (DC), Single-Fusion (SF), Extra -Signal (ES) FISH probe is designed to differentiate between a M-BCR and m-BCR gene rearrangement by giving different signal patterns.

Dewald et al., 1998, Blood, 91; 3357-3365.
Huntly et al., 2003, Blood, 102; 1160-1168.
Sharma et al., 2010, Ann Hematol, 89; 241-7.
Tkachuk et al., 1990, Science, 250; 559-56.
Kolomietz et al., 2001. Blood, 97; 3581-3588.

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