FGFR1 gene locus amplification in FFPE tissue showing an amplification of FGFR1 gene region at 8p11.
IVD FGFR1/SE 8
Amplification of the fibroblast growth factor receptor type 1 gene (FGFR1) has been observed in numerous cancer types including lung cancer (especially squamous cell carcinoma) and breast cancer. With the development of new therapeutic strategies, FGFR1 amplification could act as a valuable biomarker for R&D and provide an attractive tool for clinical stratification. The FGFR1 (8p11)/SE 8 FISH probe is optimized to detect amplification involving the FGFR1 gene region at 8p11 in a dual-color assay on paraffin embedded tissue sections. The chromosome 8 satellite enumeration probe (SE 8) at D8Z1 is included to facilitate chromosome identification.
References: Weiss et al, 2010, Sci Transl. Med. 2(62); 62ra93. Brooks et al, 2012, Clin. Cancer res. 18(7): 1855-62.