BCR / ABL1 t(9;22), Dual-Color, Single-Fusion probe hybridized to patient material showing t(9;22) translocation (1RG1R1G). Material kindly provided by Dr. Balogh, Budapest.


A simple dual-color, single-fusion assay is preferably used for the initial screening of CML and ALL patients. The Philadelphia chromosome, der(22q), is visualized by a fusion signal while the der(9q) shows no signal. The BCR/ABL1 t(9;22) FISH probe is optimized to detect the t(9;22)(q34;q11) reciprocal translocation in a dual-color, single-fusion assay on metaphase/interphase spreads, blood smears and bone marrow cells.

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