ALK (ISH)

alk-ish

ALK (2p23) Distal

The ALK (2p23) Distal - XL FISH ASR* probe is optimized to detect the genomic region distal to the ALK breakpoint(s) at 2p23.

Critical region (red): The ALK (2p23) Distal - XL FISH ASR* probe is direct-labeled with PlatinumBright 550.

ALK (2p23) Proximal

The ALK (2p23) Proximal - XL FISH ASR* probe is optimized to detect the genomic region proximal to the ALK breakpoint(s) at 2p23.

Critical region (green): The ALK (2p23) Proximal - XL FISH ASR* probe is direct-labeled with PlatinumBright 495.

ALK/EML4 t(2;2); inv(2)

The inversion in 2p21 and 2p23 leading to a fusion of the kinase domain of ALK (anaplastic lymphoma kinase) and EML4 (echinoderm microtubule associated protein like 4) has been described in 5-7% of non-small cell lung cancer (NSCLC) cases (5-7%). ALK and EML4 are ~12 MB apart in opposite directions; a simple inversion generates the fusion gene. Promising results have been obtained with specific anaplastic lymphoma kinase or ALK inhibitors like Crizotinib (PF-02341066) in patients carrying the fusion gene ALK-EML4. The ALK/EML4 t(2;2); inv(2) Fusion FISH probe is designed as a dual-color assay to detect the fusion of the ALK gene with the EML4 gene by paracentric inversion with breakage and reunion occurring at bands 2p21 and 2p23.

Literature: Soda et al., Nature, 2007, 448, 561-566.
Kwak et al, J Clin Oncol., 27(26):4247-53.
Koivunen et al. Clin Cancer Res, 2008, 14, 4275-4283.

ALK (2p23) Break

Translocations of the ALK (anaplastic lymphoma kinase) gene at 2p23 have originally been associated with anaplastic lymphomas, B-cell lymphomas, neuroblastomas and myofibroblastic tumors. To date at least 21 translocation partners have been described, however 80% of the translocations involves the NPM1 gene (5q35). More recently ALK rearrangements have been described in non-small cell lung cancer (NSCLC) cases. Promising results have been obtained with specific anaplastic lymphoma kinase or ALK inhibitors like Crizotinib (Xalkori) in patients carrying the fusion gene ALK-EML4.

  • KBI-10746
    查看可用性
    ALK (2p23) / EML4 t(2;2) inv (2) Fusion
  • KBI-10747
    查看可用性
    ALK (2p23) Break
  • KBI-XL001
    查看可用性
    ALK (2p23) Break - XL for BOND
  • KI-10746
    查看可用性
    ALK (2p23 / EML4 t(2;2); inv(2) Fusion
  • KI-10747
    查看可用性
    ALK (2p23) Break

产品规格

产品规格

KBI-10746
Lung Pathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Tissue
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent
KBI-10747
Lung Pathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Tissue
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent
KBI-XL001
Lung Pathology
In Vitro Diagnostic Use
1+1 mL
Dual Color > Red, Green
Tissue
Translocation
Gene Region-Specific
Fluorescent
10x
XL for BOND
KI-10746
Research
Research Use Only
10 test
Dual Color > Red, Green
Tissue
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent
KI-10747
Research
Research Use Only
10 test
Dual Color > Red, Green
Tissue
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

说明书

说明书

产品资料

产品资料

ALK (2p23) Distal

The ALK (2p23) Distal - XL FISH ASR* probe is optimized to detect the genomic region distal to the ALK breakpoint(s) at 2p23.

Critical region (red): The ALK (2p23) Distal - XL FISH ASR* probe is direct-labeled with PlatinumBright 550.

ALK (2p23) Proximal

The ALK (2p23) Proximal - XL FISH ASR* probe is optimized to detect the genomic region proximal to the ALK breakpoint(s) at 2p23.

Critical region (green): The ALK (2p23) Proximal - XL FISH ASR* probe is direct-labeled with PlatinumBright 495.

ALK/EML4 t(2;2); inv(2)

The inversion in 2p21 and 2p23 leading to a fusion of the kinase domain of ALK (anaplastic lymphoma kinase) and EML4 (echinoderm microtubule associated protein like 4) has been described in 5-7% of non-small cell lung cancer (NSCLC) cases (5-7%). ALK and EML4 are ~12 MB apart in opposite directions; a simple inversion generates the fusion gene. Promising results have been obtained with specific anaplastic lymphoma kinase or ALK inhibitors like Crizotinib (PF-02341066) in patients carrying the fusion gene ALK-EML4. The ALK/EML4 t(2;2); inv(2) Fusion FISH probe is designed as a dual-color assay to detect the fusion of the ALK gene with the EML4 gene by paracentric inversion with breakage and reunion occurring at bands 2p21 and 2p23.

Literature: Soda et al., Nature, 2007, 448, 561-566.
Kwak et al, J Clin Oncol., 27(26):4247-53.
Koivunen et al. Clin Cancer Res, 2008, 14, 4275-4283.

ALK (2p23) Break

Translocations of the ALK (anaplastic lymphoma kinase) gene at 2p23 have originally been associated with anaplastic lymphomas, B-cell lymphomas, neuroblastomas and myofibroblastic tumors. To date at least 21 translocation partners have been described, however 80% of the translocations involves the NPM1 gene (5q35). More recently ALK rearrangements have been described in non-small cell lung cancer (NSCLC) cases. Promising results have been obtained with specific anaplastic lymphoma kinase or ALK inhibitors like Crizotinib (Xalkori) in patients carrying the fusion gene ALK-EML4.

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