Muc-4 (Mucin 4) is an O-glycoprotein that consists of a large extracellular glycosylated subunit, transmembrane domain and intracellular domain. MUC4 is known to play a protective role for cell membrane and has anti-adhesive properties. It is understood to play a role in cancer progression, facilitating tumour progression via apoptosis inhibition. MUC4 is aberrantly expressed in several cancers including those of the bile duct, breast, colon, oesophagus, ovary, lung, prostate, stomach and pancreas.
Muc-4 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.