Human skeletal muscle: immunohistochemical staining for Merosin. Note membrane staining of normal muscle fibers (Left) and absence of staining of muscle fibers (Right). Frozen sections. Photographs supplied courtesy of Dr Louise V B Anderson. Merosin Laminin Alpha 2 Chain: clone Mer3/22B2

层黏连蛋白α2链

merosin-laminin-alpha-2-chain
肌层粘连蛋白的特异性形式,merosin,由三个链组成:α-2,β-1和γ-1。6号染色体编码基因的突变导致了一种先天性肌营养不良(CMD)。merosin阴性的CMD表现为严重的临床表型,与脑成像白质改变有关。

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