ATM (11q22) / SE 11 hybridized to patient material showing a 11q22 deletion at the ATM gene region (1R2G). Image kindly provided by Dr. Wenzel, Basel.
RUO - ATM / SE 11
Chromosome 11q22.3-23.1 deletions involving the ataxia-teleangiectasia mutated (ATM) locus are detected at diagnosis in 15-20% of cases of B-cell chronic lymphocytic leukemia (CLL) and are associated with a relatively aggressive disease. Loss of the 11q22-23 region, where the ataxia-telangiectasia mutated (ATM) gene is located, is also one of the most frequent secondary chromosomal aberrations in mantle cell lymphoma. The ATM (11q22.3) specific FISH probe is optimized to detect copy numbers of the ATM gene region at region 11q22.3. The chromosome 11 Satellite Enumeration (SE 11) at D11Z1 FISH probe is included to facilitate chromosome identification.
References: Doehner et al, 1997, Blood, 89; 2516-2522. Bigoni et al, 1997, Leukemia, 11; 1933-1940.