15q22 / 9q34 hybridized to a normal interphase/metaphase (2R2G).
RUO - 15q22 / 9q34
The hyperdiploid subtype in MM is defined by presence of multiple trisomic chromosomes. Combination of the chromosome 9q34 and 15q22 specific regions are important regions to detect the hyperdiploid subtype in MM which is usually associated with a low frequency of IGH translocations. The 15q22 and 9q34 FISH probe is designed as a dual-color assay to detect amplifications at 15q22 and 9q34.
References: Cremer et al, 2005, Genes Chrom Cancer, 44; 194-203.