15q22 / 6q21 hybridized to MM patient material with gain of both critical regions 6q21 and 15q22. Image kindly provided by Prof. Jauch, Heidelberg.
RUO - 15q22 / 6q21
Chromosome 6q amplifications encompassing 6q21-22 have been observed in MM including the same region as in CLL. Amplification including band 15q22 has been reported in MM. The 15q22 specific FISH probe is optimized to detect copy numbers at 15q22. The 6q21 specific DNA region is optimized to detect copy numbers at 6q21.
References: Cremer et al, 2005, Genes Chrom Cancer, 44; 194-203.