FOXO1 (13q14) Break probe hybridized to patient material (2RG).

IVD FOXO1 Break

ivd-foxo1-break
The t(2;13) is associated with alveolar rhabdomyo-sarcomas. This translocation results in the formation of a chimeric transcript consisting of the 5' portion of PAX3, including an intact DNA-binding domain fused to the FOXO1 gene on chromosome 13. The t(1;13)(p36;q14) also seen in alveolar rhabdomyosarcomas results in the fusion of another member of the PAX family, PAX7 to the FOXO1 gene on chromosome 13. A break or split probe for FOXO1 is best used to analyze translocation of the FOXO1 (13q14) gene on formalin fixed paraffin embedded tissue for routine clinical diagnosis. The FOXO1 (13q14) Break probe is optimized to detect translocations involving the FOXO1 gene region at 13q14 in a dual-color, split assay on metaphase/interphase spreads and paraffin embedded tissue sections.

References:
Barr et al, 1996, Hum. Mol. Genet., 5; 15-21.
Coignet et al, 1999, Genes Chrom. Cancer, 25; 222-229.

Products

Products

KBI-10716
ON FKHR (13q14) Break
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Soft Tissue Pathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Tissue
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

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