AURKB (17p13) / SE 17 probe hybridized to tumor tissue (2R2G).
Aurora kinase B (AURKB) localizes to microtubules, and is a key regulator of the mitotic cell division and chromosome segregation processes. Gain of function of AURKB correlates with cell proliferation, induction of multinuclear cells, and chromosomal instability. The significant interest of the gene in cancer diagnostics is related to the driving function of AURKB in tumor progression, histological differentiation, and metastasis. AURKB is predictive for the aggressive recurrence of many different types of tumors, including hepatocellular carcinoma and oral squamous cell carcinoma. The AURKB (17p13) FISH probe is optimized to detect copy numbers of the AURKB gene region at region 17p13. The Chromosome 17 Satellite Enumeration (SE 17) probe at D17Z1 is included to facilitate chromosome identification.
References: Smith et al, 2005, Br J Cancer, 93; 719-729.