AR (Xq12) / SE X probe hybridized to VCaP prostate cancer cell showing highlevel AR gene amplification. Image kindly provided by Prof. Trapman, Erasmus Medical Centre, Rotterdam.
IVD AR/SE X
The androgen receptor (AR) gene has been identified as a target gene for the Xq12 amplification found in one-third of hormone-refractory prostate cancers. The findings suggest that AR gene amplification and overexpression is involved in the emergence of prostate cancer. The AR (Xq12) FISH probe is optimized to detect copy numbers of the AR gene region at region Xq12. The chromosome X satellite enumeration probe (SE X) at DXZ1 is included to facilitate chromosome identification.
References: Visakorpi T et al, 1995, Nat. Genet. 9; 401-406. Koivisto P et al, 1997, Cancer Res. 57 ; 314-319.