FGFR1 (8p11) Break probe hybridization to a tissue section showing a normal pattern.
RUO - FGFR1 Break
FGFR1 has been implicated in the tumorigenesis of haematological malignancies, where it is frequently involved in balanced chromosomal translocations, including cases of chronic myeloid leukemia (BCR-FGFR1 fusion) and the 8p11 myeloproliferative syndrome/stem cell leukemia-lymphoma syndrome, which is characterized by myeloid hyperplasia and non-Hodgkin's lymphoma with chromosomal translocations fusing several genes, the most common being a fusion between ZNF198 and FGFR1. The FGFR1 (8p11) Break FISH probe is optimized to detect translocations involving the FGFR1 gene region at 8p11 in a dual-color assay on FFPE tissue sections.
References: Smedley et al, 1998, Hum Mol Genet., 7; 627-642. Sohal et al, 2001, Genes Chrom. Cancer, 32; 155-163. Kwak et al, J Clin Oncol., 27(26); 4247-53.