EGFR (7p11) / SE 7 hybridized to colon tissue (2R2G).
RUO - EGFR / SE 7
Epidermal growth factor receptor (EGFR) is a cell membrane protein, providing signal transduction and cell growth. It is a member of the Erb-B family of type I receptor tyrosine kinases and implicated in the development and progression of non-small cell lung carcinomas (NSCLC), breast, intestine, and other organs. EGFR has been found to act as a strong prognostic indicator in head and neck, ovarian, cervical, bladder and oesophageal cancers. In these cancers, increased EGFR expression was associated with reduced recurrence-free or overall survival. The EGFR (7p11) FISH probe is optimized to detect copy numbers of the EGFR gene region at region 7p11. The chromosome 7 satellite enumeration (SE 7) probe at D7Z1 is included to facilitate chromosome identification.
References: Wang et al, 1993, Jpn J Hum Genet, 38: 399-406. Nicholoset al, 2001, Eur J Cancer, 37: 9-15.