CDKN2A (9p21) / 9q21 (tissue) probe hybridized to tissue (2R2G).
RUO - CDKN2A / 9q21 (tissue)
Homozygous and hemizygous deletions of 9p21 are the earliest and most common genetic alteration in bladder cancer. The CDKN2A (INK4A) gene has been identified as tumor suppressor gene in this region which is commonly deleted in bladder cancer. The loss of DNA sequences on chromosomal bands 9p21-22 has been documented also in a variety of malignancies including leukemias, gliomas, lung cancers, and melanomas. The CDKN2A (9p21) FISH probe is optimized to detect copy numbers of the CDKN2A gene region at region 9p21. The 9q21 region probe is included to facilitate chromosome identification.
References: Stadler et al, 1994, Cancer Res, 54:2260-2063. Williams et al, 1995, Hum Mol Genet; 4: 1569-1577.