BCL2/IGH t(14;20) Fusion Probe hybridized to paraffin embedded lymph node material (2R2G). Image kindly provided by P. May, Imperial College, Hammersmith Hospital, London
RUO - BCL2 / IGH (tissue)
Follicular lymphoma is a mature B-Cell lymphoma, characterized by the presence of the t(14;18) translocation that juxtaposes the BCL2 locus on chromosome 18q21 to the immunoglobulin H (IGH) locus on chromosome 14q32, resulting in the overexpression of the antiapoptotic protein BCL2. The BCL2/IGH t(14;18) Fusion probe is optimized to detect the reciprocal translocation t(14;18) in a dual-color, dual-fusion assay on formalin fixed paraffin embedded tissue samples. In addition, Kreatech has developed a probe for the specific use on cell material (KBI-10606).
References: Taniwaki M et al, 1995, Blood, 86; 1481-1486. Poetsch M et al, 1996, J Clin Oncol, 14; 963-969.