ZNF217 (20q13) / 20q11 probe hybridized to tissue (2R2G).
Zinc-finger protein 217 (ZNF217) is a Kruppel-like zinc-finger protein located at 20q13.2, within a region of recurrent maximal amplification in a variety of tumor types, and especially breast cancer cell lines and primary breast tumors. Copy number gains at 20q13 are also found in more than 25% of cancers of the ovary, colon, head and neck, brain, and pancreas. ZNF217 is considered a strong candidate oncogene that may have profound effects on cancer progression, which is transcribed in multiple normal tissues, and overexpressed in almost all cell lines and tumors in which it is amplified. The ZNF217 (20q13) FISH probe is optimized to detect copy numbers of 20q at 20q13. The 20q11 probe is included to facilitate chromosome identification.
References: Tanner M et al, 2000, Clin Cancer Res, 6; 1833-1839. Ginestier C et al, 2006, Clin Cancer Res, 12; 4533-4544.