The MAFB / IGH t(14;20) Fusion FISH probe hybridized to patient material showing a complex pattern with a t(14;20) translocation. Image kindly provided by Erasmus Medical Center, Rotterdam.
IVD MAFB /IGH
The immunoglobulin heavy chain (IGH) gene at 14q32 is an important cause of genetic deregulation in MM. Among the known fusion partners for the IGH (previously known as IGH@) gene, reciprocal translocation with the MAFB gene at 20q12 is relatively rare in MM (~2% occurrence). However, the MAFB/IGH t(14;20) translocation is associated with poor prognosis in multiple myeloma patients. The MAFB/IGH t(14;20) Fusion FISH probe is optimized to detect the reciprocal translocation t(14;20) in a dual-color, dual-fusion assay on metaphase/interphase spreads and bone marrow cells.
References: Boersma-Vreugdenhil GR et al, 2004, Br J Haematol, 126; 355-363. Bergsagel PL et al, 2005, JCO, 23; 6333-6338.