AURKA (20q13) / 20q11 probe hybridized to colorectal carcinoma material showing amplification of AURKA, gene region at 20q13. Material kindly provided by Dr. Carvalho, Amsterdam.
Aurora kinase A (AURKA) gene amplification has been detected in approximately 12% of primary breast tumors, as well as in bladder, ovarian, colon, prostate, neuroblastoma and cervical cancer cell lines. The AURKA (20q13)/20q11 probe is designed to detect copy numbers of the AURKA gene region at region 20q13. The AURKA (20q13) FISH probe is optimized to detect copy numbers of the AURKA gene region at region 20q13. The 20q11 specific DNA probe is included to facilitate chromosome identification.
References: Uchida et al, 2010, Cancer Genet Cytogenet 203; 324-327. Sen et al, 2002, J of Nat Canc Inst 94; 1320-1329. Lassmann et al, 2007, Clin Cancer Res 13; 4083-4091.