Human kidney: immunohistochemical staining for Wilms' tumor. Note the nuclear staining of invasive tumor cells. Wilms' Tumor: clone WT49

Wilms' Tumor

wilms-tumor

Antigen Background

Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear.

Disclaimer

Wilms' Tumor is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces WT1-562-L-SWT1-562-LWT1-562-L-CE-S
    WT1-562-L-CE
    NCL-L-WT1-562,Wilms'Tumour,WT49,1mL
    WT49
    Liquid Concentrate
    P (HIER)
  • PA0562
    Wilms' Tumour
    WT49
    BOND RTU
    P (HIER)

製品仕様書

製品仕様書

WT1-562-L-CE
Uropathology
WT49
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0562
Uropathology
WT49
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

カタログ・取扱説明書など

カタログ・取扱説明書など

関連資料

関連資料

Antigen Background

Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear.

Disclaimer

Wilms' Tumor is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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