Human placenta: immunohistochemical staining for Vascular Endothelial Growth Factor Receptor-3: clone KLT9

Vascular Endothelial Growth Factor Receptor-3

vascular-endothelial-growth-factor-receptor-3

Antigen Background

VEGFR-3 (FLT4) is a receptor tyrosine kinase similar in structure to VEGFR-1 and VEGFR-2 but does not bind VEGF; however, the two known ligands have a high degree of homology to VEGF and are known as VEGF-C and VEGF-D. VEGFR-3 is reported to be found in many tissues including lung, intestine, brain and placenta (syncytiotrophoblasts). Throughout embryogenesis, VEGFR-3 mRNA is expressed in most endothelial cells, whilst being restricted to lymphatic vessels later in development. It appears to play an important role in the normal development of blood and lymphatic vessels. In tumors, expression has been reported in blood capillary endothelium and VEGFR-3 is thought to be involved in angiogenesis during tumor growth.

Disclaimer

Vascular Endothelial Growth Factor Receptor-3 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • VEGFR3-L
    NCL-L-VEGFR-3 :VRGF Receptor 3:1mL
    KLT9
    Liquid Concentrate
    P

製品仕様書

製品仕様書

VEGFR3-L
Specialized
KLT9
Liquid Concentrate
No
P
Mono
Mouse
Research Use Only
1ml

カタログ・取扱説明書など

カタログ・取扱説明書など

関連資料

関連資料

Antigen Background

VEGFR-3 (FLT4) is a receptor tyrosine kinase similar in structure to VEGFR-1 and VEGFR-2 but does not bind VEGF; however, the two known ligands have a high degree of homology to VEGF and are known as VEGF-C and VEGF-D. VEGFR-3 is reported to be found in many tissues including lung, intestine, brain and placenta (syncytiotrophoblasts). Throughout embryogenesis, VEGFR-3 mRNA is expressed in most endothelial cells, whilst being restricted to lymphatic vessels later in development. It appears to play an important role in the normal development of blood and lymphatic vessels. In tumors, expression has been reported in blood capillary endothelium and VEGFR-3 is thought to be involved in angiogenesis during tumor growth.

Disclaimer

Vascular Endothelial Growth Factor Receptor-3 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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