Transverse section of skeletal muscle fibers. immunohistochemical staining for Alpha Sarcoglycan. Note the demonstration of localized Alpha Sarcoglycan to the sarcolemma of the muscle fibers. Alpha Sarcoglycan: clone Ad1/20A6

Sarcoglycan Antibodies

sarcoglycan-antibodies

Antigen Background

In normal skeletal muscle, dystrophin, the protein product of the gene which is defective in Duchenne and Becker muscular dystrophy, is attached to the muscle membrane via a complex of proteins (dystrophin-associated glycoproteins, DAGs). Dystrophin-deficient muscle shows a generalized reduction in DAG labeling. The expression of different members of the dystrophin glycoprotein complex is altered in several types of muscular dystrophy. For example, patients with LGMD2D have mutations in the gene for alpha-sarcoglycan, those with LGM2E have mutations in the beta-sarcoglycan gene, those with LGM2C have mutations in the gamma-sarcoglycan gene and those with LGM2F have mutations in the delta-sarcoglycan gene. As the sarcoglycans function together as a sub-complex, mutations in any one of the sarcoglycan genes usually results in variable expression for the whole group.


Disclaimer

Sarcoglycan Antibodies are recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • A-SARC-L-CE
    NCL-L-a-SARC,Sarcoglycan-A,Ad1/2
    AD1/20A6
    Liquid Concentrate
    F
  • B-SARC-L-CE
    NCL-L-b-SARC,Sarcoglycan-B,βSarc
    BETASARC1/5B1
    Liquid Concentrate
    F
  • D-SARC-CE
    NCL-d-SARC,Sarcoglycan-D,δSarc3/
    DELTASARC/12C1
    Lyophilised Concentrate
    F
  • G-SARC-CE
    NCL-g-SARC,Sarcoglycan-G,35DAG/2
    35DAG/21B5
    Lyophilised Concentrate
    F

製品仕様書

製品仕様書

A-SARC-L-CE
Muscle Pathology
AD1/20A6
Liquid Concentrate
No
F
Mono
Mouse
In Vitro Diagnostic Use
1ml
B-SARC-L-CE
Muscle Pathology
BETASARC1/5B1
Liquid Concentrate
No
F
Mono
Mouse
In Vitro Diagnostic Use
1ml
D-SARC-CE
Muscle Pathology
DELTASARC/12C1
Lyophilised Concentrate
No
F
Mono
Mouse
In Vitro Diagnostic Use
1ml
G-SARC-CE
Muscle Pathology
35DAG/21B5
Lyophilised Concentrate
No
F
Mono
Mouse
In Vitro Diagnostic Use
1ml

カタログ・取扱説明書など

カタログ・取扱説明書など

関連資料

関連資料

Antigen Background

In normal skeletal muscle, dystrophin, the protein product of the gene which is defective in Duchenne and Becker muscular dystrophy, is attached to the muscle membrane via a complex of proteins (dystrophin-associated glycoproteins, DAGs). Dystrophin-deficient muscle shows a generalized reduction in DAG labeling. The expression of different members of the dystrophin glycoprotein complex is altered in several types of muscular dystrophy. For example, patients with LGMD2D have mutations in the gene for alpha-sarcoglycan, those with LGM2E have mutations in the beta-sarcoglycan gene, those with LGM2C have mutations in the gamma-sarcoglycan gene and those with LGM2F have mutations in the delta-sarcoglycan gene. As the sarcoglycans function together as a sub-complex, mutations in any one of the sarcoglycan genes usually results in variable expression for the whole group.


Disclaimer

Sarcoglycan Antibodies are recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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