Breast carcinoma, nuclear staining in a proportion of tumor cells. Paraffin section.

Progesterone Receptor

progesterone-receptor
Antigen Background
The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene.

The PRA form is a truncated version of the PRB form, lacking the first 164 N-terminal amino acids. In humans, PRA acts as a transdominant repressor of the transcriptional activity of PRB, glucocorticoid receptor, ER, androgen receptor and mineralocorticoid receptor.PRB functions mainly as a transcriptional activator. PRB is expressed strongly in endometrial glandular and stromal nuclei in the proliferative phase of the menstrual cycle and weakly during the secretory phase and early pregnancy.

Product Specific Information
Clone 16 is specific for a region of the N-terminus of the A form of PR. The precise epitope has not been mapped but it reacts with both A and B forms of PR by Western blot but only with the A form by immunohistochemistry. This suggests that the epitope is inaccessible in the native folded B form of the protein.
  • PGR-312-L-CE-S
    (医)NCL-L-PGR-312-s,PGR,16,0.1mL
    16
  • PGR-312-L-CE
    (医)NCL-L-PGR-312,PGR,16,1mL
    16
    Liquid Concentrate
    P (HIER)
  • PGR-312-L-F
    1ml NCL-L-PGR-312 - FDA
    16
    Liquid Concentrate
    P (HIER)
  • PGR-312/2-L-CE
    2ml NCL-L-PGR-312
    16
    Liquid Concentrate
    P (HIER)
  • PGR-312-L-CN
    NCL-L-PGR-312
    16
    Liquid Concentrate
    P (HIER)
    SDS
  • PGR-AB-L-CE
    NCL-L-PGR-AB,PGR(A/B),16&SAN27,1mL
    16SAN27
    Liquid Concentrate
    P (HIER)
  • PA0312
    Progesterone Receptor
    16
    BOND RTU
    P (HIER)

製品仕様書

製品仕様書

PGR-312-L-CE-S
16
In Vitro Diagnostic Use
PGR-312-L-CE
Breast Pathology
16
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PGR-312-L-F
Breast Pathology
16
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PGR-312/2-L-CE
Breast Pathology
16
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
2ml
PGR-312-L-CN
16
Liquid Concentrate
P (HIER)
In Vitro Diagnostic Use
PGR-AB-L-CE
Breast Pathology
16SAN27
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0312
Breast Pathology
16
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

カタログ・取扱説明書など

カタログ・取扱説明書など

関連資料

関連資料

Antigen Background
The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene.

The PRA form is a truncated version of the PRB form, lacking the first 164 N-terminal amino acids. In humans, PRA acts as a transdominant repressor of the transcriptional activity of PRB, glucocorticoid receptor, ER, androgen receptor and mineralocorticoid receptor.PRB functions mainly as a transcriptional activator. PRB is expressed strongly in endometrial glandular and stromal nuclei in the proliferative phase of the menstrual cycle and weakly during the secretory phase and early pregnancy.

Product Specific Information
Clone 16 is specific for a region of the N-terminus of the A form of PR. The precise epitope has not been mapped but it reacts with both A and B forms of PR by Western blot but only with the A form by immunohistochemistry. This suggests that the epitope is inaccessible in the native folded B form of the protein.

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