Human skeletal muscle: immunohistochemical staining for Merosin. Note membrane staining of normal muscle fibers (Left) and absence of staining of muscle fibers (Right). Frozen sections. Photographs supplied courtesy of Dr Louise V B Anderson. Merosin Laminin Alpha 2 Chain: clone Mer3/22B2

Merosin Laminin Alpha 2 Chain

merosin-laminin-alpha-2-chain

Antigen Background

The muscle-specific form of laminin, merosin, is composed of three chains: alpha 2, beta 1 and gamma 1.
Mutations in the chromosome 6 encoded gene for the laminin alpha 2 chain of merosin are responsible for a form of congenital muscular dystrophy (CMD). Merosin-negative CMD is characterized by a severe clinical phenotype and is associated with white matter changes on brain imaging.

Disclaimer

Merosin Laminin Alpha 2 Chain is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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MEROSIN-CE
NCL-MEROSIN,Merosin,Mer3/22B2,1m
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MER3/22B2
Muscle Pathology
Lyophilised Concentrate
No
F
Mono
Mouse
In Vitro Diagnostic Use
1ml

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