Mammaglobin is a 93 kDa glycoprotein that belongs to the uteroglobin family of proteins. It was first described in 1996 and found to be overexpressed in breast cancer. Published reports suggest a role for mammaglobin in the diagnosis of metastatic breast carcinoma.
Mammaglobin has been suggested as a useful marker for carcinomas of unknown primary origin, with expression unaltered from the primary site. Additional published data suggests a role for mammaglobin in the migration and invasion of breast cancer cells.
Human ductal carcinoma of breast: immunohistochemical staining for Mammaglobin protein. Note cytoplasmic staining of a proportion of malignant cells. Mammaglobin: clone EP249