B cell chronic lymphocytic leukemia: immunohistochemical staining for Lambda Light Chain. Note the neoplastic cells show a moderate and distinct predominantly membrane staining reaction. Occasional plasma cells show a strong staining reaction. Lambda Light Chain: clone SHL53

Lambda Light Chain

lambda-light-chain

Antigen Background

The basic structure of an immunoglobulin molecule consists of two identical heavy chains, either gamma, alpha, delta, or epsilon and two identical light chains, either kappa or lambda. Any heavy chain can associate with either light chain but on any immunoglobulin molecule both light chains are of the same type. The ratio of kappa and lambda light chains varies between Ig classes and subclasses. In a polyclonal population the ratio of kappa to lambda bearing B cells is approximately 2:1, with individual B cells thought to express kappa or lambda light chains, never both. The majority of kappa and lambda chains are bound to heavy chain immunoglobulin, however in normal individuals low levels of free light chain are present in serum. The occurrence of a mixture of kappa and lambda chain expressing cells suggests a polyclonal population and a reactive or non-neoplastic proliferation of B cells.

Disclaimer

Lambda Light Chain is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces LAM-578-LLAM-578-L-SLAMLAMPLAM-578-L-CE-SLAM-A
    LAM-578-L-CE
    NCL-L-LAM-578,Lambda,SHL53,1mL
    SHL53
    Liquid Concentrate
    P (HIER)
  • PA0570
    Lambda Light Chain(SHL53),BOND RTU,7mL
    SHL53
    BOND RTU
    P (HIER)

製品仕様書

製品仕様書

LAM-578-L-CE
Hematopathology
SHL53
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0570
Hematopathology
SHL53
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

カタログ・取扱説明書など

カタログ・取扱説明書など

関連資料

関連資料

Antigen Background

The basic structure of an immunoglobulin molecule consists of two identical heavy chains, either gamma, alpha, delta, or epsilon and two identical light chains, either kappa or lambda. Any heavy chain can associate with either light chain but on any immunoglobulin molecule both light chains are of the same type. The ratio of kappa and lambda light chains varies between Ig classes and subclasses. In a polyclonal population the ratio of kappa to lambda bearing B cells is approximately 2:1, with individual B cells thought to express kappa or lambda light chains, never both. The majority of kappa and lambda chains are bound to heavy chain immunoglobulin, however in normal individuals low levels of free light chain are present in serum. The occurrence of a mixture of kappa and lambda chain expressing cells suggests a polyclonal population and a reactive or non-neoplastic proliferation of B cells.

Disclaimer

Lambda Light Chain is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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