Helicobacter pylori is a motile, helix-shaped Gram-negative, microaerophilic, bacterial pathogen which is capable of converting from a spiral form to a coccoid form to favor its survival. Almost 50 percent of the world's population, approaching 100 percent in some countries, are infected. There are numerous strains of Helicobacter pylori which can be grouped into two broad families, type I and type II, based on their expression of the hopQ allele. Type I and type II strains are reported to express VacA (vacuolating toxin) responsible for vacuolation of gastric epithelial cells and induction of apoptosis. Type I strains are reported to express CagA protein which is associated with deregulation of intercellular signalling pathways and initiation of pathogenesis (virulent strains) and are closely related to gastric diseases such as peptic ulceration, gastric ulceration, chronic gastritis, mucosaassociated lymphoid tissue (MALT) lymphoma and intestine type gastric adenocarcinomas. Type II strains are reported not to express CagA proteins. HopE is a 31 kD porin protein which is part of a family of 32 outer membrane proteins present in Helicobacter pylori bacteria. HopE is highly conserved in Helicobacter pylori strains, but not among other strains of the Helicobacter genus.
Product Specific Information
Clone ULC3R, unlike polyclonal antibodies to Helicobacter pylori, does not cross-react with Campylobacter jejuni (a gastric bacterium which causes infective diarrhoea). Clone ULC3R also exhibits more defined staining of H. pylori bacteria than NCL-HPp. The antibody clone ULC3R, will be useful to identify and differentiate patients that need antibiotic eradication of the bacterium from those patients who are at a higher risk of developing clinical disease related to H. pylori infection.