Invasive breast carcinoma: immunohistochemical staining for E-Cadherin. Note the membrane and cytoplasmic staining of tumor cells. E-Cadherin: clone 36B5

E-Cadherin

e-cadherin

Antigen Background

E-cadherin is a Ca2+-dependent, transmembrane cell adhesion molecule. It plays an important role in the growth, development and the intercellular adhesion of epithelial cells. Most tumors have an abnormal architecture and any subsequent loss of adhesiveness is thought to be an important step in the development of local invasion. E-cadherin may have a role in neoplastic progression, particularly as a suppressor of invasion. In prostate cancers, for example, the expression of E-cadherin is reported to be reduced or absent in comparison with its expression in normal prostate which is uniformly strong. Reduced expression or absence of E-cadherin in addition to alpha, beta and gamma-catenin in primary breast carcinomas has also been reported and these four proteins are associated with the development of metastases.

E-Cadherin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • E-CAD-L-CE
    NCL-L-E-Cad,E-Cadherin,36B5,1mL
    36B5
    Liquid Concentrate
    P (HIER)
    SDS(pdf) Datasheet(pdf)
  • PA0387
    E-Cadherin
    36B5
    BOND RTU
    P (HIER)
    SDS(pdf) Datasheet(pdf)

製品仕様書

製品仕様書

E-CAD-L-CE
Breast Pathology
36B5
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0387
Breast Pathology
36B5
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

カタログ・取扱説明書など

カタログ・取扱説明書など

関連資料

関連資料

Antigen Background

E-cadherin is a Ca2+-dependent, transmembrane cell adhesion molecule. It plays an important role in the growth, development and the intercellular adhesion of epithelial cells. Most tumors have an abnormal architecture and any subsequent loss of adhesiveness is thought to be an important step in the development of local invasion. E-cadherin may have a role in neoplastic progression, particularly as a suppressor of invasion. In prostate cancers, for example, the expression of E-cadherin is reported to be reduced or absent in comparison with its expression in normal prostate which is uniformly strong. Reduced expression or absence of E-cadherin in addition to alpha, beta and gamma-catenin in primary breast carcinomas has also been reported and these four proteins are associated with the development of metastases.

E-Cadherin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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