Advancing Cancer Diagnostics, Improving Lives
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Antigen Background
Cytokeratin 20は、胃および腸上皮、尿路上皮、皮膚のメルケル細胞にほぼ限定することが証明されています。（Cytokeratin 20 は、他のI 型Cytokeratinよりも酸性度が低く、組織発現が限定しているため関心が持たれています。Cytokeratin 20は、正常組織では腸上皮、胃小窩上皮、幽門腺における多数の内分泌細胞、尿路上皮および表皮のメルケル細胞に発現し、また腫瘍のタイプによりCytokeratin20発現に顕著な差があることが報告されています。Cytokeratin 20を発現する腫瘍は、それをもともと発現していた正常上皮に由来します。大腸癌はCytokeratin20を常に発現しますが、胃癌での発現は低レベルです。胆嚢と胆管の腺癌、膵管癌、粘液性卵巣腫瘍、メルケル細胞腫瘍および尿路上皮癌がCytokeratin 20を発現することも報告されています。
Disclaimer
Cytokeratin 20 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.\
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