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The characteristic chromosomal abnormality in Synovial Sarcoma t(X;18)(p11.2;q11.2) is present in 90% of the patients. This translocation results in the fusion of the synovial sarcoma translocation, chromosome 18 (SS18) gene to either of two distinct genes, SSX1 or SSX2, located on the X chromosome. The SS18 (18q11) Break probe is optimized to detect translocations involving the SS18 gene region at 18q11 in a dual-color, split assay on paraffin embedded tissue sections.
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