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Deletions of the long arm of chromosome 11 (11q) have been noted in primary neuroblastomas. It is assumed that a tumor suppressor gene mapping within 11q23.3 is commonly inactivated during the malignant evolution of a large subset of neuroblastomas, especially those with unamplified MYCN. The KMT2A (11q23) FISH probe is optimized to detect amplification or deletion involving the KMT2A gene region at 11q23 in a dual-color assay. The Chromosome 11 Satellite Enumeration probe (SE 11) at D11Z1 is included to facilitate chromosome identification.
Guo et al, 1999, Oncogene, 18: 4948-4957.
Maris et al, 2001, Med Pediatr Oncol, 36: 24-27.