CCDN1 (11q13) / SE 11 probe hybridized to patient interphases / metaphase showing CCDN1 (11q13) amplification with polyploidy for chromosome 11.
RUO - CCND1 /SE 11
The binding of cyclin D1 (also named CCND1 or BCL1) to cyclin-dependent kinases (CDKs) leads to the phosphorylation of retinoblastoma protein (pRb), subsequently triggering the release of E2F transcription factors to allow G1 to S phase progression of the cell cycle. Consistent with this function, overexpression of cyclin D1 results in a more rapid progression from the G1 to S phase transition and in a reduced serum dependency in fibroblast cells, characteristics typically seen in cancer cells. The CCND1 (11q13) FISH probe is optimized to detect copy numbers of the CCND1 gene region at region 11q13. The Chromosome 11 Satellite Enumeration (SE 11) probe at D11Z1 is included to facilitate chromosome identification.
References: Okami et al, 1999, Oncogene 18; 3541-3645. Freier et al, 2003, Cancer Res; 1179-1182.