6q21 / SE 6 probe hybridized to a normal metaphase (2R2G).
RUO - 6q21 / SE 6
Deletions affecting the long arm of chromosome 6 (6q) are among the most commonly observed chromosomal aberrations in lymphoid malignancies and have been identified as an adverse prognostic factor in subsets of tumors including CLL. A minimal deletion region has been identified within a 2-megabase segment of 6q21, between D6S447 and D6S246. The SEC63 gene is located within this critical region. The 6q21 specific FISH probe is optimized to detect copy numbers of 6q at region 6q21.The chromosome 6 Satellite Enumeration FISH probe (SE 6) at D6Z1 is included to facilitate chromosome identification.
References: Sherratt et al, 1997, Chromosome Res, 5; 118-124. Zhang et al, 2000, Genes Chrom Cancer, 27; 52-58.