Human tonsil: immunohistochemical staing for CD23. Note intense staining of follicular dendritic cell network and weaker staining of mantle zone cells. CD23: clone 1B12
CD23
cd23
Antigen Background
The CD23 molecule is the low affinity IgE receptor found on B cells.It is a membrane glycoprotein of 45 kD and is reported to be found on a sub-population of peripheral blood cells, B lymphocytes and on EBV-transformed B lymphoblastoid cell lines.
Expression of CD23 antigen has been reported on monocytes and dendritic cells.
Disclaimer
CD23 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.