The most common chromosomal translocation in multiple myeloma (MM) is t(11;14), resulting in up-regulation of cyclin D1. In MM the breakpoints are scattered within a 360-kb region between CCND1 and MYEOV. This breakpoint is more proximal than the t(11;14) breakpoints observed in mantle cell lymphoma or other leukemias. Patients with MM who have t(11;14)(q13;q32) seem to have an aggressive clinical course. The MYEOV / IGH t(11;14)(q13;q32) Fusion specific FISH probe is optimized to detect the reciprocal translocation t(11;14) in a dual-color, dual-fusion assay.
References:
Janssen et al., 2000, Blood, 95; 2691-2698.
Fonseca et al, 2002, Blood, 99; 3735-3741.
