Hybridization of IGH break probe to a tissue section showing normal and aberrant pattern (2RG)(1RG1R1G)
RUO - IGH Break (tissue)
Chromosomal rearrangements involving the immunoglobulin heavy chain gene (IGH) at 14q32 are observed in 50% of patients with B-cell non-Hodgkin's lymphoma (NHL) and many other types of Lymphomas. More than 50 translocation partners with IGH have been described. In particular t(8;14) is associated with Burkitt's lymphoma, t(11;14) is associated with Mantle cell lymphoma, t(14;18) is observed in a high proportion of follicular lymphomas and t(3;14) is associated with Diffuse Large B-Cell Lymphoma. The IGH (14q32) Break probe is optimized to detect translocations involving the IGH gene region at 14q32 in a dual-color, split assay.
References: Taniwaki et al, 1994, Blood, 83: 2962-1969. Gozetti et al, 2002, Cancer Research, 62: 5523-5527.