dic(9;20) Triple-Color. Image kindly provided by Dr. Ann Nordgren, Stockholm.
RUO - dic(9;20)
The dic(9;20)(p13.2;q11.2) is a recurrent chromosomal abnormality in pediatric Bcell precursor acute lymphoblastic leukemia (BCP-ALL), which occurs in ~2% of the cases. It is associated with an intermediate outcome with relapses being relatively frequent, compared to other common cytogenetic subgroups of BCP-ALL (e.g. high hyperploidy and t(12;21)). The dic(9;20) is an unbalanced rearrangement involving chromosomes 9 and 20, resulting in the co-localisation of the respective centromeres and concomitant loss of the chromosome arms 9p and 20q. The dic(9;20) Triple-Color FISH probe is optimized to detect the dicentric (9;20)(p13.2;q11.2) in a triple-color assay on metaphase/interphase spreads, blood smears and bone marrow cells.
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