Mm-BCR / ABL1 probe hybridized to patient material showing t(9;22) with M-BCR (1F1r1R1G).
Breakpoints in the BCR gene region can occur in different regions, predominantly in a major breakpoint cluster region (M-BCR) but can also occur in a minor breakpoint cluster region (m-BCR) or micro breakpoint cluster region (µ-BCR). Further research has indicated that CML patients with different BCR-ABL1 transcripts respond differently to treatment with Gleevec. The Mm-BCR/ABL1 t(9;22), Dual-Color (DC), Single-Fusion (SF), Extra -Signal (ES) FISH probe is designed to differentiate between a M-BCR and m-BCR gene rearrangement by giving different signal patterns.
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