Human B cell chronic lymphocytic leukemia: immunohistochemical staining for ZAP-70 antigen. Note staining of malignant lymphocytic leukemic cells and intense staining of infiltrating T lymphocytes. ZAP-70: clone L453R

ZAP-70

zap-70

Antigen Background

ZAP-70 is a member of the syk family of proteins. It is expressed on T cells and NK cells and is required for the T cell receptor activation that triggers an immune response. CLL B cells that express the non-mutated immunoglobulin VH genes express levels of ZAP-70 protein that are comparable to those found in the blood T cells of healthy adults. Leukemic cells that express mutated Ig VH genes generally do not express detectable levels of ZAP-70 protein and this is correlated with the high level expression of CD38.

Disclaimer

ZAP-70 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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ZAP-70-L-CE
1ml NCL-L-ZAP-70
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PA0998
7ml ZAP-70 Bond RTU Primary
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ZAP-70-L-CE

PA0998

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