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34E12 reacts with human cytokeratin intermediate filament proteins 1, 5, 10 and 14. The antibody is reported to react with squamous epithelium and sweat ducts in normal skin, some pneumocytes, bronchial epithelium and mesothelium in normal lung and bile ducts in normal liver. It also reacts with ductal cells of the normal pancreas, some acinar and ductal cells of normal breast, some follicular epithelia of normal thyroid and some epithelia and mesothelium of the normal small and large bowel.
Cytokeratin (High Molecular Weight) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
Holy See (Vatican City State)