Antigen Background
The CD45RO molecule, a 180 kD isoform of CD45, is reported to be expressed on 48% of peripheral blood T lymphocytes, 37% of CD4 positive lymphocytes, 80% of thymocytes and on the majority of T cell malignancies. Monocytes and granulocytes show surface expression of the antigen whereas tissue macrophages exhibit cytoplasmic expression.
Disclaimer
CD45RO is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
