It appears that your browser has cookies disabled.
The website requires your browser to enable cookies in order to login.
Please enable cookies and reload this page.
Log In
Register for an account
Don't have a login? Register today to view list prices and apply for an account to purchase online!
Antigen Background
CD31 antigen (PECAM-1) is a single chain transmembrane glycoprotein with a molecular weight of 130 to 140 kD. The CD31 molecule is expressed on the surface of platelets, monocytes, granulocytes, B cells and at the endothelial intracellular junction. The molecule has an extracellular domain that contains six Ig-like homology units of C2 subclass, typical of cell to cell adhesion molecules. This domain mediates endothelial cell to cell adhesion, plays a role in endothelial contact and may serve to stabilize the endothelial cell monolayer. The CD31 molecule also has a cytoplasmic domain with potential sites for phosphorylation after cellular activation. The properties of CD31 antigen suggest that it is involved in interactive events during angiogenesis, thrombosis and wound healing. Angiogenesis is essential for tumor growth and metastases.
Disclaimer
CD31 (PECAM-1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
Andorra
Australia
Austria
Belgium
Canada
China
Denmark
Finland
France
French Guiana
Germany
Guadeloupe
Holy See (Vatican City State)
Hong Kong
Ireland
Italy
Japan
Liechtenstein
Luxembourg
Martinique
Netherlands
New Caledonia
New Zealand
Norway
Philippines
Portugal
Reunion
Singapore
Spain
Sweden
Switzerland
Taiwan
Thailand
United Kingdom
Vietnam
Andorra
Australia
Austria
Belgium
Canada
China
Denmark
Finland
France
French Guiana
Germany
Guadeloupe
Holy See (Vatican City State)
Hong Kong
Ireland
Italy
Japan
Liechtenstein
Luxembourg
Malaysia
Martinique
Myanmar
Netherlands
New Caledonia
New Zealand
Norway
Philippines
Portugal
Reunion
Singapore
Spain
Sweden
Switzerland
Taiwan
Thailand
United Kingdom
Vietnam
Australia
Austria
Belgium
Brunei Darussalam
Canada
China
Denmark
Finland
France
French Guiana
Germany
Guadeloupe
Holy See (Vatican City State)
Hong Kong
Ireland
Italy
Japan
Liechtenstein
Luxembourg
Martinique
Myanmar
Netherlands
New Caledonia
New Zealand
Norway
Philippines
Portugal
Reunion
Singapore
South Korea
Spain
Sweden
Switzerland
Taiwan
Thailand
United Kingdom
Vietnam