Human colon polyp: immunohistochemical staining for Beta-Catenin. Note the abnormal translocation of the protein to the nucleus. Beta-Catenin: clone 17C2

Beta-Catenin

beta-catenin

Antigen Background

The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer.

Disclaimer

Beta-Catenin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Products

Products

B-CAT-L-CE
1ml NCL-L-B-CAT
Country availability

Contact Us for a quote.

This item replaces B-CAT-L-UB-CAT-U
17C2
Soft Tissue Pathology
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0083
7ml Beta-Catenin Bond RTU Primary
Country availability

Contact Us for a quote.

This item replaces B-CATB-CAT-S
17C2
Soft Tissue Pathology
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Downloads

Downloads

B-CAT-L-CE

PA0083

Recently Viewed