Human follicular lymphoma: neoplastic cells show a moderate, predominantly cytoplasmic staining reaction. Bcl-2: clone bcl-2/100/D5

bcl-2 Oncoprotein

bcl-2-oncoprotein

Antigen Background

Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway.

In 90% of follicular lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.

Disclaimer

Bcl-2 Oncoprotein is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Products

Products

BCL-2-L-CE
1ml NCL-L-bcl-2
Country availability

Contact Us for a quote.

This item replaces BCL-2-CE-SBCL-2BCL-2-CEBCL-2-486BCL-2-SBCL-2-OBCL-2-486-UBCL-2-R-7-CEBCL-2-486-S
BCL-2/100/D5
Hematopathology
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
BCL-2-L
1ml NCL-L-bcl-2
Country availability

Contact Us for a quote.

This item replaces BCL-2-R-7
BCL-2/100/D5
Hematopathology
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
Research Use Only
1ml
PA0117
7ml Bcl-2 Bond RTU Primary
Country availability

Contact Us for a quote.

BCL-2/100/D5
Hematopathology
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Downloads

Downloads

BCL-2-L-CE

BCL-2-L

PA0117

Recently Viewed