Anaplastic large cell lymphoma: immunohistochemical staining for ALK. Note the strong nuclear and cytoplasmic staining in the neoplastic cells. ALK: clone 5A4

ALK

alk

Antigen Background

Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and epithelial membrane antigen (EMA). These tumor cells tend to occur in younger individuals and may be associated with cutaneous and extranodal involvement. A proportion of these cases contain a chromosomal translocation t(2;5) (p23;q35). This results in a hybrid gene encoding part of the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large cell lymphomas account for approximately 25% of all non-Hodgkin's lymphomas in children and young adults, of which one third carry the NPM-ALK gene translocation.

Disclaimer

ALK is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
 

Products

Products

ALK-L-H
0.5ml NCL-L-ALK
Country availability

Contact Us for a quote.

5A4
Hematopathology
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
Research Use Only
0.5ml
ALK-L-CE-H
0.5ml NCL-L-ALK
Country availability

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This item replaces ALK-L-CE-SALK-L-SALKALK-CEALK-CE-S
5A4
Hematopathology
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
0.5ml
PA0306
7ml ALK Bond RTU Primary
Country availability

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5A4
Hematopathology
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0831
7 mL ALK (5A4) BOND RTU Primary
Country availability

Contact Us for a quote.

5A4
Hematopathology
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Downloads

Downloads

ALK-L-H

ALK-L-CE-H

PA0306

PA0831

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